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J Allergy Clin Immunol. 2015 Nov Carlsson CJ, Vissing NH, Sevelsted A, Johnston SL, Bønnelykke K, Bisgaard H. Abstract BACKGROUND: Wheezy episodes in young children are often triggered by viral and bacterial respiratory tract infections, but there is little evidence supporting the hypothesis that symptom duration depends on the specific microbial trigger. OBJECTIVE: We soughtRead more

Eur Respir J. 2015 Nov Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, Pandis I, Bansal AT, Bel EH, Auffray C, Compton CH, Bisgaard H, Bucchioni E, Caruso M, Chanez P, Dahlén B, Dahlen SE, Dyson K, Frey U, Geiser T, Gerhardsson de Verdier M, Gibeon D, Guo YK, Hashimoto S,Read more

Eur Respir J. 2015 Nov Fleming L1, Murray C2, Bansal AT3, Hashimoto S4, Bisgaard H5, Bush A6, Frey U7, Hedlin G8, Singer F9, van Aalderen WM10, Vissing NH5, Zolkipli Z11, Selby A11, Fowler S12, Shaw D13, Chung KF1, Sousa AR14, Wagers S15, Corfield J16, Pandis I17, Rowe A18, Formaggio E19, Sterk PJ4, Roberts G20; U-BIOPREDRead more

Br J Nutr. 2015 Sep Muc M, Kreiner-Møller E, Larsen JM, Birch S, Brix S, Bisgaard H, Lauritzen L. Abstract Breast milk long-chain PUFA (LCPUFA) have been associated with changes in early life immune responses and may modulate T-cell function in infancy. We studied the effect of maternal fatty acid desaturase (FADS) genotype and breastRead more

J Allergy Clin Immunol. 2015 Jul Association between respiratory infections in early life and later asthma is independent of virus type. Bønnelykke K, Vissing NH, Sevelsted A, Johnston SL, Bisgaard H. Abstract BACKGROUND: Lower respiratory tract infections in the first years of life are associated with later asthma, and this observation has led to aRead more

Nature. 2015 Jul Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, Okada Y, Stančáková A, Faul JD, Zhao W, Bartz TM, Concas MP, Franceschini N, Enroth S, Vitart V, Trompet S, Guo X, Chasman DI, O’Connel JR, Corre T, Nongmaithem SS, Chen Y,Read more

J Allergy Clin Immunol. 2015 Jun Chawes BL, Stokholm J, Bønnelykke K, Brix S, Bisgaard H. Abstract BACKGROUND: Children and adults with asthma and impaired lung function have been reported to have low-grade systemic inflammation, but it is unknown whether this inflammation starts before symptoms and in particular whether low-grade inflammation is present in asymptomaticRead more

Hum Mol Genet. 2015 Feb van der Valk RJ, Kreiner-Møller E, Kooijman MN, Guxens M, Stergiakouli E, Sääf A, Bradfield JP, Geller F, Hayes MG, Cousminer DL, Körner A, Thiering E, Curtin JA, Myhre R, Huikari V, Joro R, Kerkhof M, Warrington NM, Pitkänen N, Ntalla I, Horikoshi M, Veijola R, Freathy RM, Teo YY,Read more

Pulm Pharmacol Ther. 2015 Feb Govoni M, Piccinno A, Lucci G, Poli G, Acerbi D, Baronio R, Singh D, Kuna P, Chawes BL, Bisgaard H. Abstract BACKGROUND: Asthma guidelines recommend prescription of inhaled corticosteroids at a reduced dosage in children compared to older patients in order to minimize the systemic exposure and risk of unwantedRead more

Pediatr Pulmonol. 2015 Feb Chawes BL1, Bischoff AL, Kreiner-Møller E, Buchvald F, Hakonarson H, Bisgaard H. Abstract RATIONALE OF THE STUDY: Increased neonatal fraction of exhaled nitric oxide (FeNO) is associated with lung symptoms early in life, while predictors of neonatal FeNO levels are unknown. The objective of this study was to investigate perinatal andRead more