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J Allergy Clin Immunol. 2015 Jan West CE, Renz H, Jenmalm MC, Kozyrskyj AL, Allen KJ, Vuillermin P, Prescott SL; in-FLAME Microbiome Interest Group. Abstract Rapid environmental transition and modern lifestyles are likely driving changes in the biodiversity of the human gut microbiota. With clear effects on physiologic, immunologic, and metabolic processes in human health,Read more

Pediatr Infect Dis J. 2015 Jan Bischoff AL1, Følsgaard NV, Vissing NH, Birch S, Brix S, Bisgaard H. Abstract BACKGROUND: It is recommended to vaccinate pregnant women against influenza. A possible impact on the immune expression of the fetus has never been studied. We aim to study the immune signature in the upper airways andRead more

Allergy. 2015 Jan Kreiner-Møller E1, Strachan DP, Linneberg A, Husemoen LL, Bisgaard H, Bønnelykke K. Abstract BACKGROUND: 17q21 gene variants are the strongest known genetic determinants for childhood asthma and have been reported to interact with environmental tobacco smoke exposure in childhood. It remains unclear whether individuals with 17q21 risk variants have increased risk ofRead more

Allergy. 2015 Jan. Schoos AM1, Chawes BL, Følsgaard NV, Samandari N, Bønnelykke K, Bisgaard H. Abstract BACKGROUND: Skin prick test (SPT) and measurement of serum-specific IgE (sIgE) level are important tools for the clinician to diagnose allergic sensitization. However, little is known about the agreement between the two methods in young children. METHODS: SPT andRead more

Pediatrics. 2015 Jan Sevelsted A, Stokholm J, Bønnelykke K, Bisgaard H. Abstract OBJECTIVES: Immune diseases such as asthma, allergy, inflammatory bowel disease, and type 1 diabetes have shown a parallel increase in prevalence during recent decades in westernized countries. The rate of cesarean delivery has also increased in this period and has been associated withRead more

J Allergy Clin Immunol. 2014 Nov Kreiner-Møller E, Bisgaard H, Bønnelykke K. Abstract BACKGROUND: It is unknown to what extent adult lung function genes affect lung function development from birth to childhood. OBJECTIVE: Our aim was to study the association of candidate genetic variants with neonatal lung function and lung function development until age 7Read more

Lancet Respir Med. 2014 Aug Stokholm J, Sevelsted A, Bønnelykke K, Bisgaard H. Abstract BACKGROUND: Maternal use of antibiotics during pregnancy has been associated with the development of asthmatic disorders in the offspring. The human microbiome has been suggested to act as an intermediary in this process. To provide clarification on this theory, we studiedRead more

Respir Med. 2014 Aug Chawes BL, Govoni M, Kreiner-Møller E, Vissing NH, Poorisrisak P, Mortensen L, Nilsson E, Bisgaard A, Dossing A, Deleuran M, Skytt NL, Samandari N, Piccinno A, Sergio F, Ciurlia G, Poli G, Acerbi D, Singh D, Bisgaard H. Abstract AIM: Prescription of inhaled corticosteroids to children with asthma is recommended atRead more

Ugeskr Laeger. 2014 Jul 14 Bisgaard H, Jacobsen S, Tvede N, Langhoff-Roos J. Abstract A woman with systemic lupus erythematosus (SLE) and lupus nephritis had two pregnancies which both resulted in complications known to be associated with SLE, i.e. late abortion, preterm delivery and pre-eclampsia. We conclude that disease quiescence is important for a successfulRead more

J Allergy Clin Immunol. 2014 Jul van der Valk RJ1, Duijts L, Timpson NJ, Salam MT, Standl M, Curtin JA, Genuneit J, Kerhof M, Kreiner-Møller E, Cáceres A, Gref A, Liang LL, Taal HR, Bouzigon E, Demenais F, Nadif R, Ober C, Thompson EE, Estrada K, Hofman A, Uitterlinden AG, van Duijn C, Rivadeneira F,Read more