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Am J Respir Crit Care Med. 2013 Nov 15 Vissing NH1, Chawes BL, Bisgaard H. Abstract RATIONALE: The frequency of pneumonia and bronchiolitis exhibits considerable variation in otherwise healthy children, and suspected risk factors explain only a minor proportion of the variation. We hypothesized that alterations in the airway microbiome in early life may beRead more

Clin Exp Allergy. 2013 Nov Kreiner-Møller E1, Chawes BL, Vissing NH, Koppelman GH, Postma DS, Madsen JS, Olsen DA, Baty F, Vonk JM, Kerkhof M, Sleiman P, Hakonarsson H, Mortensen LJ, Poorisrisak P, Bisgaard H, Bønnelykke K. Abstract BACKGROUND: Vascular endothelial growth factor (VEGF) is implicated in airway remodelling and asthma development. We studied VEGFARead more

Pediatr Res. 2013 Sep Brasholt M1, Chawes B, Kreiner-Møller E, Vahlkvist S, Sinding M, Bisgaard H. Abstract BACKGROUND: The aim of this study was to examine in detail levels and patterns of physical activity in preschool children and the effects of gender and BMI on this activity. METHODS: Two hundred and fifty-three children aged 5Read more

Eur J Clin Nutr. 2013 Sep Carlsen K1, Pedersen L, Bønnelykke K, Stark KD, Lauritzen L, Bisgaard H. Abstract BACKGROUND/OBJECTIVES: Studies suggest that intake of marine n-3 polyunsaturated fatty acids (n-3 PUFA) in pregnancy have an impact on birth weight, but only few have investigated the effect on early fetal growth. The objective of theRead more

Nat Genet. 2013 Aug Bønnelykke K1, Matheson MC, Pers TH, Granell R, Strachan DP, Alves AC, Linneberg A, Curtin JA, Warrington NM, Standl M, Kerkhof M, Jonsdottir I, Bukvic BK, Kaakinen M, Sleimann P, Thorleifsson G, Thorsteinsdottir U, Schramm K, Baltic S, Kreiner-Møller E, Simpson A, St Pourcain B, Coin L, Hui J, Walters EH,Read more

Ugeskr Laeger. 2013 Aug 12 [Article in Danish] Bønnelykke K, Pedersen S, Rubak SL, Schiøtz O, Bisgaard H. Abstract These clinical guidelines were developed by the Danish Pediatric Asthma Center in collaboration with the Danish Paediatric Society. Key messages in the guidelines are: 1) Inhaled steroids are the most effective preventive medication and are firstRead more

PLoS One. 2013 Jul 30 Vissing NH1, Sevelsted A, Bisgaard H. Abstract BACKGROUND: During the 2009 H1N1 pandemic the Danish National board of Health carried out massive public hygiene campaigns to limit spread of disease. We aimed to investigate whether this resulted in lower incidences of communicable diseases in the paediatric population. METHODS: The studyRead more

Hum Mol Genet. 2013 Jul Cousminer DL, Berry DJ, Timpson NJ, Ang W, Thiering E, Byrne EM, Taal HR, Huikari V, Bradfield JP, Kerkhof M, Groen-Blokhuis MM, Kreiner-Møller E, Marinelli M, Holst C, Leinonen JT, Perry JR, Surakka I, Pietiläinen O, Kettunen J, Anttila V, Kaakinen M, Sovio U, Pouta A, Das S, Lagou V,Read more

J Clin Pharmacol. 2013 May Bønnelykke K, Chawes BL, Vindfeld S, Moore AC, Bisgaard H. Abstract In vitro measures of aerosol particles size, such as the fine particle mass, play a pivotal role for approval of inhaled anti-asthmatic drugs. However, the validity as a measure of dose to the lungs in children lacks evidence. InRead more

PLoS One. 2013 Apr 18 Bischoff AL1, Følsgaard NV, Carson CG, Stokholm J, Pedersen L, Holmberg M, Bisgaard A, Birch S, Tsai TF, Bisgaard H. Abstract BACKGROUND: Pregnant women were suspected to be at particular risk when H1N1pnd09 influenza became pandemic in 2009. Our primary objective was to compare the immune responses conferred by MF59®-adjuvantedRead more