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J Pediatr. 2013 Apr Stensballe LG, Simonsen J, Jensen SM, Bønnelykke K, Bisgaard H. Abstract OBJECTIVES: To investigate the hypothesis that mother’s use of antibiotics in pregnancy could influence asthma and eczema in early life. STUDY DESIGN: Subjects were included from the Copenhagen Prospective Study on Asthma in Childhood cohort of children born of mothersRead more

Br J Clin Pharmacol. 2013 Apr Chawes BL1, Piccinno A, Kreiner-Møller E, Vissing NH, Poorisrisak P, Mortensen L, Nilson E, Bisgaard A, Dossing A, Deleuran M, Skytt NL, Samandari N, Sergio F, Ciurlia G, Poli G, Acerbi D, Bisgaard H. Abstract AIM: The fixed combination of beclomethasone (BDP) and formoterol pressurized metered dose inhaler (pMDI)Read more

N Engl J Med. 2013 Apr 11 Calışkan M, Bochkov YA, Kreiner-Møller E, Bønnelykke K, Stein MM, Du G, Bisgaard H, Jackson DJ, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C. Abstract BACKGROUND: Both genetic variation at the 17q21 locus and virus-induced respiratory wheezing illnesses are associated with the development of asthma. Our aimRead more

Genome Res. 2013 Apr Jakobsen JS1, Waage J, Rapin N, Bisgaard HC, Larsen FS, Porse BT. Abstract Dynamic shifts in transcription factor binding are central to the regulation of biological processes by allowing rapid changes in gene transcription. However, very few genome-wide studies have examined how transcription factor occupancy is coordinated temporally in vivo inRead more

Am J Respir Crit Care Med. 2013 Mar Følsgaard NV1, Schjørring S, Chawes BL, Rasmussen MA, Krogfelt KA, Brix S, Bisgaard H. Abstract RATIONALE: Bacterial colonization of neonatal airways with the pathogenic bacterial species, Moraxella catarrhalis, Streptococcus pneumoniae, and Haemophilus influenzae, is associated with later development of childhood asthma. OBJECTIVES: To study a possible associationRead more

Nat Genet. 2013 Jan Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, Bradfield JP, St Pourcain B, Evans DM, Charoen P, Kaakinen M, Cousminer DL, Lehtimäki T, Kreiner-Møller E, Warrington NM, Bustamante M, Feenstra B, Berry DJ, Thiering E, Pfab T, Barton SJ, Shields BM, Kerkhof M, van Leeuwen EM, FulfordRead more

Pediatr Res. 2012 Dec Pedersen L, Lauritzen L, Brasholt M, Buhl T, Bisgaard H. Abstract BACKGROUND: The consumption of polyunsaturated fatty acids has changed, and the prevalence of adiposity has increased over the past 30 y. A decrease of n-3 polyunsaturated fatty acid content in breast milk has been suggested to be a contributing factor.Read more

Chest. 2012 Dec Malby Schoos AM, Chawes BL, Bønnelykke K, Bisgaard H. Abstract BACKGROUND: Elevated fraction of exhaled nitric oxide (FENO) and bronchial hyperresponsiveness are used as surrogate markers of asthma. These traits may be continuous in the population. The objective of this study was to investigate whether FENO and bronchial responsiveness are associated inRead more

Clin Exp Allergy. 2012 Nov Kreiner-Møller E1, Chawes BL, Caye-Thomasen P, Bønnelykke K, Bisgaard H. Abstract BACKGROUND: Childhood otitis media with effusion is a common disease and a link to allergic diseases has been suggested. OBJECTIVE: To investigate the association between atopic disease and otitis media with effusion diagnosed according to strict objective case definitionsRead more

Clin Exp Allergy. 2012 Nov Følsgaard NV1, Chawes BL, Bønnelykke K, Jenmalm MC, Bisgaard H. Abstract BACKGROUND: Early-life immune deviation is suspected in the inception of atopic disease. OBJECTIVE: To investigate the association between cord blood chemokines and the subsequent development of atopic biomarkers and clinical end-points during the first 6 years of life. METHODS:Read more