J Eur Acad Dermatol Venereol. 2012 Mar Thyssen JP, Carlsen BC, Bisgaard H, Giwercman C, Johansen JD, Linneberg A, Meldgaard M, Szecsi PB, Stender S, Menné T. Abstract BACKGROUND: About 8-10% of the general population in Europe carry a null mutation in the filaggrin gene which is associated with early onset of atopic dermatitis asRead more
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Thorax. 2012 Mar Iskandar A1, Andersen ZJ, Bønnelykke K, Ellermann T, Andersen KK, Bisgaard H. Abstract BACKGROUND: Short-term exposure to air pollution can trigger hospital admissions for asthma in children, but it is not known which components of air pollution are most important. There are no available studies on the particular effect of ultrafine particlesRead more
Am J Respir Crit Care Med. 2012 Feb 1 Følsgaard NV, Chawes BL, Rasmussen MA, Bischoff AL, Carson CG, Stokholm J, Pedersen L, Hansel TT, Bønnelykke K, Brix S, Bisgaard H. Abstract RATIONALE: Heredity from mother or father may impact differently in complex diseases, such as atopy. Maternal atopy is a stronger risk factor thanRead more
Dev Biol. 2012 Feb 1 Kalisz M1, Winzi M, Bisgaard HC, Serup P. Abstract TGFß signaling patterns the primitive streak, yet little is known about transcriptional effectors that mediate the cell fate choices during streak-like development in mammalian embryos and in embryonic stem (ES) cells. Here we demonstrate that cross-antagonistic actions of EVEN-SKIPPED HOMEOBOX 1Read more
Br J Dermatol. 2012 Jan Thyssen JP1 Ross-Hansen K, Johansen JD, Zachariae C, Carlsen BC, Linneberg A, Bisgaard H, Carson CG, Nielsen NH, Meldgaard M, Szecsi PB, Stender S, Menné T. Abstract BACKGROUND: Filaggrin metabolites act as osmolytes and are important for skin hydration. Carriers of filaggrin loss-of-function mutations have a higher prevalence of atopicRead more
Nat Genet. 2011 Dec Paternoster L, Stand M, Chen CM, Ramasamy A, Bønnelykke K, Duijts L, Ferreira MA, Alves AC, Thyssen JP, Albrecht E, Baurecht H, Feenstra B, Sleiman PM, Hysi P, Warrington NM, Curjuric I, Myhre R, Curtin JA, Groen-Blokhuis MM, Kerkhof M, Sääf A, Franke A, Ellinghaus D, Fölster-Holst R, Dermitzakis E, MontgomeryRead more
Thorax. 2011 Oct Bel EH1, Sousa A, Fleming L, Bush A, Chung KF, Versnel J, Wagener AH, Wagers SS, Sterk PJ, Compton CH; Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome (U-BIOPRED) Consortium, Consensus Generation. Abstract Patients with severe refractory asthma pose a major healthcare problem. Over the last decade it has become increasinglyRead more
BMC Dev Biol. 2011 Sep 26 Vestentoft PS, Jelnes P, Hopkinson BM, Vainer B, Møllgård K, Quistorff B, Bisgaard HC. Abstract BACKGROUND: During liver development, intrahepatic bile ducts are thought to arise by a unique asymmetric mode of cholangiocyte tubulogenesis characterized by a series of remodeling stages. Moreover, in liver diseases, cells lining the CanalsRead more
J Allergy Clin Immunol. 2011 Sep Bisgaard H1, Li N, Bonnelykke K, Chawes BL, Skov T, Paludan-Müller G, Stokholm J, Smith B, Krogfelt KA. Abstract BACKGROUND: Changes in the human microbiome have been suggested as a risk factor for a number of lifestyle-related disorders, such as atopic diseases, possibly through a modifying influence on immuneRead more
Am J Respir Crit Care Med. 2011 Sep 15 Chawes BL, Bønnelykke K, Bisgaard H. Abstract RATIONALE: Biomarkers predicting development of atopic disease are needed for targeted preventive measures and to study if disease pathology may be active before onset of symptoms. OBJECTIVES: To investigate whether eosinophil protein X, leukotriene-C4/D4/E4, and 11β-prostaglandin (PG) F2α (PGD2Read more
