Thorax. 2008 Aug Andersen ZJ, Loft S, Ketzel M, Stage M, Scheike T, Hermansen MN, Bisgaard H. Abstract BACKGROUND: There is limited evidence for the role of air pollution in the development and triggering of wheezing symptoms in young children. A study was undertaken to examine the effect of exposure to air pollution on wheezingRead more
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PLoS Med. 2008 Jun 24 Bisgaard H, Simpson A, Palmer CN, Bønnelykke K, McLean I, Mukhopadhyay S, Pipper CB, Halkjaer LB, Lipworth B, Hankinson J, Woodcock A, Custovic A. Abstract BACKGROUND: Loss-of-function variants in the gene encoding filaggrin (FLG) are major determinants of eczema. We hypothesized that weakening of the physical barrier in FLG-deficient individualsRead more
Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood.
Pediatr Pulmonol. 2008 Jun Kjaer BB, Jensen JS, Nielsen KG, Fomsgaard A, Böttiger B, Dohn B, Bisgaard H. Abstract Mycoplasma (M.) pneumoniae has been associated with exacerbation of symptoms in asthmatic school children and adults; and an etiological role in asthma has been suggested. The purpose of this study was to investigate whether infection withRead more
J Allergy Clin Immunol. 2008 Apr Bisgaard H, Bønnelykke K. Comment on Comparative study of budesonide inhalation suspension and montelukast in young children with mild persistent asthma. [J Allergy Clin Immunol. 2007] PMID: 18325574Read more
Virchows Arch. 2008 Apr Dezso K1, Halász J, Bisgaard HC, Paku S, Turányi E, Schaff Z, Nagy P. Abstract Delta-like protein (DLK) is a membrane protein with mostly unknown function. It is expressed by several embryonic tissues among others by the hepatoblasts of rodent and human fetal livers. We have investigated in the present studyRead more
J Allergy Clin Immunol. 2008 Mar Bønnelykke K, Pipper CB, Bisgaard H. Abstract BACKGROUND: Intrauterine sensitization has been suggested to play a role in the development of atopic disease in children, and this has led to current guidelines recommending allergen avoidance during pregnancy. OBJECTIVE: To investigate the relevance of allergen-specific IgE in cord blood toRead more
Pediatrics. 2008 Mar Thomsen SF, Stensballe LG, Skytthe A, Kyvik KO, Backer V, Bisgaard H. Abstract OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors. METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born inRead more
Chest. 2008 Jan Loland L, Bisgaard H. Abstract BACKGROUND: The aim of the study was to evaluate the feasibility of lung function measurements by the raised volume rapid thoracoabdominal compression (RVRTC) technique during bronchial methacholine challenge in young infants. METHOD: Four hundred two healthy infants were tested at 1 month of age with RVRTC duringRead more
Br J Dermatol. 2007 Dec Lerbaek A, Bisgaard H, Agner T, Ohm Kyvik K, Palmer CN, Menné T. Abstract BACKGROUND: The filaggrin protein is a key component of stratum corneum and homo- or heterozygotes for the filaggrin variant alleles R501X and 2282del4 have varying degrees of impaired skin barrier. The variant alleles have repeatedly beenRead more
Am J Pathol. 2007 Nov Dezso K1, Jelnes P, László V, Baghy K, Bödör C, Paku S, Tygstrup N, Bisgaard HC, Nagy P. Abstract Thy-1, a marker of hematopoietic stem cells, has been reported to be expressed by oval cells proliferating during stem cell-mediated regeneration in rat liver, suggesting a relationship between the two cellRead more
