Allergy. 1998 Apr Pedersen W, Hjuler I, Bisgaard H, Mygind N. Abstract The standard treatment of allergic rhinitis and asthma consists of topical corticosteroids administered intranasally and inhaled through the mouth. Although this therapy is highly effective, and side-effects are few and mild, it may be possible further to improve the therapeutic index and patientRead more
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Lab Invest. 1998 Mar Bisgaard HC, Santoni-Rugiu E, Nagy P, Thorgeirsson SS. Abstract The proteolytic cascade involving plasminogen activators and plasmin appears to have an important function in tissue regeneration. We have investigated the expression and cellular localization of urokinase-type plasminogen activator (uPA), tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator receptor (uPAR), and plasminogen activatorRead more
Am J Respir Crit Care Med. 1998 Feb Bisgaard H. Abstract This article describes a new “automatic spacer” device, which has been developed to improve the delivery of inhaled medication to young children. In the device, a dry powder inhaler (DPI) is mechanically actuated into a nonelectrostatic spacer, producing an aerosol cloud of fine drugRead more
Eur Respir J. 1998 Feb Nielsen KG, Auk IL, Bojsen K, Ifversen M, Klug B, Bisgaard H. Abstract In vitro studies with the Diskus inhaler at low and high flow rates show consistent doses of drug as fine particles or = 30 L x min(-1) through the device, while 26% performed > or = 90Read more
Respir Med. 1998 Jan Bisgaard H, Nikander K, Munch E. Abstract The study objective was to compare the effect of budesonide administered as a nebulized suspension as compared to a spray with a spacer in adult asthmatics. In a double-blind, double-dummy crossover study, 26 adult patients with moderately severe unstable asthma were randomized to threeRead more
Am J Respir Crit Care Med. 1997 Oct Bisgaard H1, Pedersen SS, Nielsen KG, Skov M, Laursen EM, Kronborg G, Reimert CM, Høiby N, Koch C. Abstract The efficacy and safety of anti-inflammatory treatment with inhaled glucocorticosteroids in patients with cystic fibrosis (CF) and complicating chronic Pseudomonas aeruginosa (P.a.) lung infection was studied in aRead more
Eur Respir J. 1997 Oct Ellerman A, Bisgaard H. Abstract Patients with primary ciliary dyskinesia (PCD) have pronounced stasis of their respiratory secretions and therefore recurrent lower airway infections, which raises concerns for the development of lung function. Twenty four patients with PCD have been studied prospectively with a standardized regime in our clinic forRead more
Eur Respir J. 1997 Sep Nielsen KG1, Skov M, Klug B, Ifversen M, Bisgaard H. Abstract The output and size distribution of aerosols from dry powder inhalers are dependent on the flow rate through the device. Therefore, in an in vivo study, we examined the flow-dependency of the effect of formoterol when delivered from aRead more
Pediatr Pulmonol Suppl. 1997 Sep Bisgaard H. Abstract Inhaled corticosteroids reduce asthma symptoms and exacerbations, improve lung function, and reduce airway inflammation and bronchial hyperreactivity more effectively than other treatments. However, inhaled corticosteroids may be unable to return lung function and bronchial hyperreactivity to normal when introduced for moderately severe asthma. This finding highlights theRead more
Eur Respir J. 1997 Jul Klug B, Bisgaard H. Abstract The purpose of this study was to evaluate a procedure for measurement of specific airway resistance (sRaw) by whole body plethysmography in young awake children accompanied by an adult. sRaw was measured by a single-step procedure, omitting the measurement of the thoracic gas volume. TheRead more
