Hepatology. 1991 Apr Diehl AM1, Bisgaard HC, Kren BT, Steer CJ. Abstract The effects of chronic ethanol consumption on enzyme systems involved in carcinogen activation and detoxification were studied in a rat model of liver regeneration. In control rats, steady-state messenger RNAs of cytochrome P450j decreased 12 to 24 hr after partial hepatectomy but wereRead more
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Acta Paediatr Scand. 1991 Feb Bisgaard H, Pedersen S, Damkjaer Nielsen M, Osterballe O. Abstract The effect of the inhaled topical steroid budesonide on adrenal function was evaluated in 33 children (aged 7-15 years) with moderate bronchial asthma. The trial was designed as a prospective single-blind study of the effect of budesonide in daily dosesRead more
Mol Carcinog. 1991 Gant TW, Silverman JA, Bisgaard HC, Burt RK, Marino PA, Thorgeirsson SS. Abstract Previous studies by this laboratory have indicated that expression of the multidrug resistance (mdr) gene can be increased in vivo by exposure to a variety of xenobiotics. Because of the nature of these compounds, it was proposed that mdrRead more
Allergy. 1991 Jan Clementsen P, Milman N, Struve-Christensen E, Petersen BN, Pedersen M, Bisgaard H, Permin H, Norn S. Abstract Histamine release induced by Staphylococcus aureus was examined in cells obtained by bronchoalveolar lavage (BAL) in non-atopic individuals. Approximately half of the individuals responded with mediator release to the bacterium, and the release was foundRead more
Lancet. 1990 Sep 15 Bisgaard H, Munck SL, Nielsen JP, Petersen W, Ohlsson SV. Abstract 77 children, aged 11 to 36 months (mean 24) with moderately severe recurrent wheezing, were treated with budesonide pressurised aerosol 400 micrograms twice daily or placebo for 12 weeks in a double-blind, parallel-group trial. Aerosols were inhaled from a spacerRead more
Food Chem Toxicol. 1989 Nov Lam HR, Bisgaard HC. Abstract Groups of seven male Wistar rats were dermally exposed for 24 hr to 556 mumol [14C]meta-phenylenediamine (MPD; 1,3-diaminobenzene) in either aqueous solution (Group 2) or 4% hydrogen peroxide (Group 3). The percutaneous absorption and the amount of non-excreted radioactivity were significantly higher in Group 2Read more
Acta Derm Venereol. 1989 Lerche A, Bisgaard H, Kassis V, Christensen JD, Søndergaard J. Abstract Ten nickel-allergic patients and 5 healthy control subjects participated in a study of the kinetics of the flux and concentration of migrated leukocytes and extracellular PGE1 and PGF2 alpha during a 48 h period, using a skin chamber technique. TheRead more
Toxicol In Vitro. 1989 Bisgaard HC1, Lam HR. Abstract The metabolism of the aromatic amine 1,3-diaminobenzene (MPD) was studied in vitro by use of the perfused rat liver, primary rat hepatocyte cultures and hepatic rat microsomes. The metabolites formed were compared with urinary metabolites excreted by the rat in vivo. Metabolites of [(14)C]MPD excreted byRead more
J Allergy Clin Immunol. 1988 Jun Bisgaard H, Damkjaer Nielsen M, Andersen B, Andersen P, Foged N, Fuglsang G, Høst A, Leth C, Pedersen M, Pelck I, et al. Abstract The effect of inhaled beclomethasone dipropionate and budesonide on the adrenal function was studied in 30 children (aged 7 to 15 years) with mild bronchialRead more
Allergy. 1988 Apr Bisgaard H, Robinson C, Rømeling F, Mygind N, Church M, Holgate ST. Abstract We have examined the measurements of LTC4 and histamine in nasal lavage fluids and blown secretions as a possible model of the early mediator events during nasal allergy. A nasal challenge with grass pollen extract was undertaken on twoRead more
