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Clin Exp Allergy. 2012 Nov Følsgaard NV1, Chawes BL, Bønnelykke K, Jenmalm MC, Bisgaard H. Abstract BACKGROUND: Early-life immune deviation is suspected in the inception of atopic disease. OBJECTIVE: To investigate the association between cord blood chemokines and the subsequent development of atopic biomarkers and clinical end-points during the first 6 years of life. METHODS:Read more

BMC Med Res Methodol. 2012 Oct Vissing NH, Jensen SM, Bisgaard H. Abstract BACKGROUND: The longitudinal birth cohort study is the preferred design for studies of childhood health, particularly atopic disease. Still, prospective data collection depends on recollection of the medical history since the previous visit representing a potential recall-bias. We aimed to ascertain theRead more

J Allergy Clin Immunol. 2012 Aug Chawes BL1, Poorisrisak P, Johnston SL, Bisgaard H. Abstract BACKGROUND: Respiratory syncytial virus and other respiratory tract viruses lead to common colds in most infants, whereas a minority develop acute severe bronchiolitis often requiring hospitalization. We hypothesized that such an excessive response to respiratory tract viral infection is causedRead more

J Allergy Clin Immunol. 2012 Aug Skytt N, Bønnelykke K, Bisgaard H. Abstract BACKGROUND: The diagnosis of asthma in young children is difficult and based on clinical assessment of symptoms and results of physical examination. Respiratory wheeze has traditionally been used to define asthma in young children. OBJECTIVE: We sought to compare the qualitative diagnosisRead more

PLoS One. 2012 Stokholm J1, Schjørring S, Pedersen L, Bischoff AL, Følsgaard N, Carson CG, Chawes B, Bønnelykke K, Mølgaard A, Krogfelt KA, Bisgaard H. Abstract BACKGROUND: Furred pets in the household are known reservoirs for pathogenic bacteria, but it is not known if transmission of bacteria between pet and owner leads to significantly increasedRead more

PLoS One. 2012 Carson CG1, Rasmussen MA, Thyssen JP, Menné T, Bisgaard H. Abstract BACKGROUND: Filaggrin null mutations result in impaired skin barrier functions, increase the risk of early onset atopic dermatitis and lead to a more severe and chronic disease. We aimed to characterize the clinical presentation and course of atopic dermatitis associated withRead more

PLoS One. 2012 Carson CG, Halkjaer LB, Jensen SM, Bisgaard H. Abstract BACKGROUND: Atopic dermatitis has increased four-fold over the recent decades in developed countries, indicating that changes in environmental factors associated with lifestyle may play an important role in this epidemic. It has been proposed that alcohol consumption may be one contributing risk factorRead more

Am J Respir Crit Care Med. 2012 Jun Bisgaard H, Jensen SM, Bønnelykke K. Abstract RATIONALE: The causal direction between asthma and lung function deficit is unknown, but important for the focus of preventive measures and research into the origins of asthma. OBJECTIVES: To analyze the interaction between lung function development and asthma from birthRead more

Nat Genet. 2012 May Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, Hypponen E, Holst C, Valcarcel B, Thiering E, Salem RM, Schumacher FR, Cousminer DL, Sleiman PM, Zhao J, Berkowitz RI, Vimaleswaran KS, Jarick I, Pennell CE, Evans DM, St Pourcain B, Berry DJ, Mook-Kanamori DO, Hofman A, Rivadeneira F,Read more

Allergy. 2012 May Sevelsted A1, Bisgaard H. Abstract BACKGROUND: We hypothesized that anthropometrics in the newborn is associated with development of asthma later in life. METHODS: The study included a prospective, longitudinal clinical study of a birth cohort of 411 Danish neonates born at term of mothers with a history of asthma. The primary endpointRead more