Chest. 2006 Dec Bisgaard H1, Le Roux P, Bjåmer D, Dymek A, Vermeulen JH, Hultquist C. Abstract OBJECTIVES: A fixed combination of long-acting beta(2)-agonists (LABA) plus inhaled corticosteroids (ICS) has never been proven to reduce asthma exacerbations vs ICS alone in children. This 12-month, double-blind, randomized study in 341 children (age range, 4 to 11Read more
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Endocrinology. 2006 Dec Jackerott M, Lee YC, Møllgård K, Kofod H, Jensen J, Rohleder S, Neubauer N, Gaarn LW, Lykke J, Dodge R, Dalgaard LT, Søstrup B, Jensen DB, Thim L, Nexø E, Thams P, Bisgaard HC, Nielsen JH. Abstract Trefoil factors (TFFs) 1, 2, and 3 are expressed in mucosal epithelia. TFFs are particularRead more
Arch Dis Child. 2006 Dec Gammelgaard A, Knudsen LE, Bisgaard H. Abstract OBJECTIVE: To analyse the motivations and perceptions of parents on the participation of their infants and young children in a comprehensive and invasive clinical research study. METHODS: Semistructured qualitative interviews were conducted with 23 mothers with asthma whose infants and young children wereRead more
Am J Clin Nutr. 2006 Jul Lauritzen L, Halkjaer LB, Mikkelsen TB, Olsen SF, Michaelsen KF, Loland L, Bisgaard H. Abstract BACKGROUND: Atopic dermatitis has been related to a disturbed metabolism of polyunsaturated fatty acids (PUFAs). OBJECTIVE: We tested whether the PUFA composition of breast milk differs significantly between mothers with atopic dermatitis, mothers withRead more
J Allergy Clin Immunol. 2006 Jun Vahlkvist S1, Sinding M, Skamstrup K, Bisgaard H. Abstract BACKGROUND: Fractional exhaled nitric oxide (FENO) is a sensitive marker of eosinophilic airway inflammation in asthma. Available methods have restricted measurements to the clinic, giving only a snapshot of the disease, which by nature is highly variable. OBJECTIVES: We soughtRead more
Chest. 2006 May Hermansen MN1, Nielsen KG, Buchvald F, Jespersen JJ, Bengtsson T, Bisgaard H. Abstract STUDY OBJECTIVE: To compare the acute bronchodilatory effect of the long-acting beta2-agonist formoterol against the short-acting beta2-agonist (SABA) terbutaline during exercise-induced bronchoconstriction (EIB) in children with asthma. DESIGN: A randomized, double-blind, placebo-controlled, crossover study of the immediate effect ofRead more
N Engl J Med. 2006 May 11 Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Abstract BACKGROUND: We hypothesized that asthma is preceded by a stage of recurrent episodes of wheezing during the first years of life and that inhaled corticosteroid therapy during symptomatic episodes in this early phase may delay progression toRead more
Arch Dermatol. 2006 May Halkjaer LB, Loland L, Buchvald FF, Agner T, Skov L, Strand M, Bisgaard H. Abstract OBJECTIVES: To describe the development of atopic dermatitis (AD) during the first 3 years of life and identify the localization of the early skin lesions that predicts the development of AD. DESIGN: Prospective, longitudinal, birth cohortRead more
Nat Genet. 2006 Apr Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, O’Regan GM, Watson RM, Cecil JE, Bale SJ, Compton JG, DiGiovanna JJ, Fleckman P, Lewis-Jones S, Arseculeratne G, Sergeant A, Munro CS, El Houate B, McElreavey K, Halkjaer LB, Bisgaard H,Read more
Chest. 2006 Mar Loland L1, Buchvald FF, Halkjaer LB, Anhøj J, Hall GL, Persson T, Krause TG, Bisgaard H. Abstract OBJECTIVES: There is limited evidence on the preferred methods for evaluating lung function in infancy. The objective of this study was to compare sensitivity and repeatability of indexes of lung function in young infants duringRead more
