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Am J Respir Crit Care Med. 2005 Feb 1 Nielsen KG1, Bisgaard H. Abstract Cold air challenge (CACh) has been shown to discriminate between children with asthma and healthy young children. Hyperventilation with dry room-temperature air is a simplified alternative. We compared responsiveness in young children with asthma between two standardized, single-step protocols: dry airRead more

Am J Respir Crit Care Med. 2005 Jan 15 O’Byrne PM, Bisgaard H, Godard PP, Pistolesi M, Palmqvist M, Zhu Y, Ekström T, Bateman ED. Abstract Asthma control is improved by combining inhaled corticosteroids with long-acting beta2-agonists. However, fluctuating asthma control still occurs. We hypothesized that in patients receiving low maintenance dose budesonide/formoterol (bud/form), replacingRead more

Biochem Biophys Res Commun. 2004 Dec 10 Li B, Bisgaard HC, Forbes VE. Abstract The polychaete Capitella capitata sp.I has a high capacity to metabolize polycyclic aromatic hydrocarbons (PAHs) which are among the most hazardous environmental pollutants with significant biological effects. In the present study, two novel cytochrome P450 (CYP) genes were identified in thisRead more

Ann Allergy Asthma Immunol. 2004 Oct Bisgaard H. Abstract BACKGROUND: The atopic diseases asthma, atopic dermatitis, and allergic rhinitis are the most common chronic diseases in children, and their prevalence has increased recently in industrialized nations. Little is known about the genetic-environmental interaction factors driving such proliferation. OBJECTIVE: To investigate the relationships among genetic, environmental,Read more

Respir Med. 2004 Jun Holgate ST, Bousquet J, Chung KF, Bisgaard H, Pauwels R, Fabbri L, Rabe K, Doherty M, Snell NJ, Cuss F, D’Amato M, Reginster JY; Group for the Respect of Ethics and Excellence in Science: Asthma section. Abstract With new drugs being introduced to treat asthma it is timely to review criteriaRead more

Am J Respir Crit Care Med. 2004 Jun 1 Nielsen KG, Pressler T, Klug B, Koch C, Bisgaard H. Abstract In a 4-year prospective study, we evaluated specific airway resistance (sRaw) by whole-body plethysmography, respiratory resistance by the interrupter technique, and respiratory resistance and reactance at 5 Hz by the impulse oscillation technique combined withRead more

Chest. 2004 May;125(5):1680-4. Kocevar VS, Bisgaard H, Jönsson L, Valovirta E, Kristensen F, Yin DD, Thomas J 3rd. Abstract BACKGROUND: We assessed variations in hospitalization parameters and costs among asthmatic children in four Nordic countries by geographic location and age groups. METHODS: Cross-sectional, county-level aggregate data on asthma-related hospitalizations in 1999, obtained from public nationalRead more

Ann Hum Biol. 2004 May-Jun Heitmann BL, Anhøj J, Bisgaard AM, Ward L, Bisgaard H. Abstract PRIMARY OBJECTIVE: The study aimed to examine the changes in water distribution in the soft tissue during systemic steroid activity. RESEARCH DESIGN: A three-way cross-over, randomized, placebo-controlled, double-blind trial was used, including 4 weeks of fluticasone propionate pMDI 200Read more

Am J Pathol. 2004 Apr Jensen CH1, Jauho EI, Santoni-Rugiu E, Holmskov U, Teisner B, Tygstrup N, Bisgaard HC. Abstract Hepatic regeneration from toxic or surgical injury to the adult mammalian liver, endorses different cellular responses within the hepatic lineage. The molecular mechanisms determining commitment of a cell population at a specific lineage level toRead more

Pediatrics. 2004 Feb Bisgaard H, Allen D, Milanowski J, Kalev I, Willits L, Davies P. Abstract OBJECTIVE: Our aim was to compare the 12-month safety and efficacy of fluticasone propionate (FP) and sodium cromoglycate (SCG) in children aged 1 to 3 years with mild to moderate recurrent wheeze. METHODS: The study was a randomized, parallel-group,Read more