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Am J Respir Crit Care Med. 2000 Jul Bisgaard H, Nielsen KG. Abstract We hypothesized that a leukotriene receptor antagonist (LTRA) could provide bronchoprotection against the cold, dry air-induced response in asthmatic preschool children. In a randomized, double-blind, placebo-controlled crossover study, we examined the effect of the specific LTRA montelukast at 5 mg/d for 2Read more

Mutat Res. 2000 Jun 30 Rasmussen LJ, Rasmussen M, Lee B, Rasmussen AK, Wilson DM 3rd, Nielsen FC, Bisgaard HC. Abstract Mutations in DNA mismatch repair (MMR) genes have been shown to segregate with Hereditary Nonpolyposis Colorectal Cancer (HNPCC). However, because many HNPCC families fail to display mutations in known MMR genes, we argued thatRead more

Am J Respir Crit Care Med. 2000 Jun Nielsen KG1, Bisgaard H. Abstract The aim of the study was to assess feasibility, sensitivity, specificity, predictive value, and repeatability of cold, dry air challenge (CACh) as a diagnostic test for asthma in young children 2 to 5 yr of age. Response to a 4-min single-step isocapnicRead more

Respir Med. 2000 Jun Bjermer L1, Bisgaard H, Bousquet J, Fabbri LM, Greening A, Haahtela T, Holgate ST, Picado C, Leff JA. Abstract Asthma patients who continue to experience symptoms despite taking regular inhaled corticosteroids represent a management challenge. Leukotrienes play a key role in asthma pathophysiology, and since pro-inflammatory leukotrienes are poorly suppressed byRead more

Biochem Biophys Res Commun. 2000 Jun 7 Nagy P, Bisgaard HC, Schnur J, Thorgeirsson SS. Abstract We have investigated the expression of several growth-related genes in the liver after partial hepatectomy in three experimental models: normal, Dexamethasone-pretreated, and hypophysectomized rats. Dexamethasone and hypophysectomy resulted in a delay in the peak of cell replication in 6Read more

Exp Cell Res. 2000 May 25 Rasmussen LJ, Rasmussen M, Lützen A, Bisgaard HC, Singh KK. Abstract DNA damage caused by alkylating agents results in a G2 checkpoint arrest. DNA mismatch repair (MMR) deficient cells are resistant to killing by alkylating agents and are unable to arrest the cell cycle in G2 phase after alkylationRead more

Pediatr Pulmonol. 2000 Mar Bisgaard H. Abstract This review assesses the evidence regarding the use of long-acting beta(2)-agonists in the management of pediatric asthma. Thirty double-blind, randomized, controlled trials on the effects of formoterol and salmeterol on lung function in asthmatic children were identified. Single doses of inhaled salmeterol or formoterol cause prolonged bronchodilatation (>12Read more

Biochem Biophys Res Commun. 1999 Nov 19 Thulstrup PW1, Thormann T, Spanget-Larsen J, Bisgaard HC. Abstract The interaction between ellagic acid and DNA has been characterized with respect to the geometry of the ellagic acid-DNA complex, and the active form of ellagic acid has been identified. Optical spectroscopic methods have been employed to examine theRead more

Eur Respir J. 1999 Nov Klug B, Bisgaard H. Abstract The aims of this study were to investigate lung function in 2-5-yr-old stable asthmatic children consecutively referred from general practitioners and to analyse the outcome on the basis of their requirement for antiasthmatic treatment and symptoms after 1.6-4.5 yrs. Lung function was measured in 110Read more

Am J Respir Crit Care Med. 1999 Oct Bisgaard H, Loland L, Oj JA. Abstract Nitric oxide in exhaled air (FENO) is increased in asthmatic children, probably reflecting aspects of airway inflammation. We have studied the effect of the leukotriene receptor antagonist (LTRA) montelukast on FENO with a view to elucidate potential anti-inflammatory properties ofRead more