Am J Pathol. 1999 Oct Bisgaard HC, Müller S, Nagy P, Rasmussen LJ, Thorgeirsson SS. Abstract Suppression subtractive hybridization was used to clone genes associated with proliferation of oval cells in rat liver regenerating after a 70% partial hepatectomy combined with the feeding of 2-acetylaminofluorene. A subset of the identified genes comprised interferon-gamma receptor alphaRead more
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Pediatr Pulmonol. 1999 Sep Nikander K, Bisgaard H. Abstract The aim of the present study was to compare the output of a breath-synchronized jet nebulizer to a conventional constant output nebulizer over a fixed period of time in terms of inhaled mass of budesonide, i.e., the amount of budesonide deposited on a filter interposed betweenRead more
J Aerosol Med. 1999 Fall Zak M, Madsen J, Berg E, Bülow J, Bisgaard H. Abstract A mathematical model of aerosol delivery from holding chambers (spacers) was developed incorporating tidal volume (VT), chamber volume (Vch), apparatus dead space (VD), effect of valve insufficiency and other leaks, loss of aerosol by immediate impact on the chamberRead more
Am J Respir Crit Care Med. 1999 Jul Bisgaard H, Gillies J, Groenewald M, Maden C. Abstract The response in asthmatic young children to inhaled steroids within the usual pediatric dose range is unknown. We therefore evaluated the dose-related response in young children with moderate asthma to inhaled fluticasone propionate (FP) (delivered via the BabyhalerRead more
Br J Clin Pharmacol. 1999 Mar Anhøj J, Bisgaard H, Lipworth BJ. Abstract AIMS: The effect of the electrostatic charge in plastic spacers in vivo on drug delivery to the lung of hydrofluoroalkane (HFA) salbutamol spray was studied in children. METHODS: Five children, aged 7-12 years, were included in a 3-way crossover randomised single-blind trial.Read more
Allergy. 1999 Bisgaard H. Abstract There is an increasing awareness of the importance of reliable aerosol delivery, with emphasis on the dose delivered to the lungs, optimal clinical control, cost-effectiveness, and safety in children. Dose prescription should relate to the expected lung dose rather than the factory-dispensed dose, as at present. The device determines theRead more
Allergy. 1999 Mygind N, Bisgaard H, Dahl R. PMID: 10565489Read more
Rhinology. 1998 Dec Borum S1, Nielsen K, Bisgaard H, Mygind N. Abstract In allergic rhinitis, a nasal H1-antihistamine spray seems to be well suited for usage on an as-needed basis, because it has a quick onset of action, and many patients prefer to take medicine only when they have symptoms. It is a prerequisite, however,Read more
Eur Respir J. 1998 Aug Berg E, Madsen J, Bisgaard H. Abstract The performance of pressurized metered dose inhalers (pMDIs) and spacers in correct dose recommendations is important, but limited information on dose delivery and fine-particle dose from different combinations of spacers and pMDIs is available. In this study, three combinations of spacers and pMDIsRead more
Pediatr Pulmonol. 1998 May Klug B, Bisgaard H. Abstract We report data on respiratory function in healthy children aged 2-7 years in whom we measured respiratory resistance by the interrupter technique (Rint); total respiratory impedance (Zrs), respiratory resistance (Rrs), and reactance (Xrs) by the impulse oscillation technique; and specific airway resistance (sRaw) by a modifiedRead more
