Hepatology. 1996 Jan Bisgaard HC, Nagy P, Santoni-Rugiu E, Thorgeirsson SS. Abstract In this study, we used [3H]thymidine labeling of newly synthesized DNA to examine the earliest effects of 2-acetylaminofluorene (2-AAF) on the mitotic activation of cells in the adult rat liver, and in situ hybridization analysis to study the expression of three transcription factorsRead more
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Hepatology. 1996 Jan Nagy P, Bisgaard HC, Santoni-Rugiu E, Thorgeirsson SS. Abstract Expression of several growth factors is elevated in rat liver, after induction of oval cell proliferation by chemical carcinogens. However, the exact roles played by individual factors are not defined. We infused and examined the effects of epidermal growth factor (EGF) and hepatocyteRead more
Clin Lab Med. 1996 Jun Bisgaard HC, Thorgeirsson SS. Abstract Hepatic necrosis is a common reaction to liver injury of various etiologies. The response is regeneration. As reviewed earlier, reconstitution of liver mass may proceed via two mechanisms: (1) re-entry of surviving, functionally intact differentiated liver cells into the cell cycle, where they may remainRead more
Arch Dis Child. 1995 Sep Bisgaard H, Anhøj J, Klug B, Berg E. Abstract A pear shaped non-electrostatic spacer, composed of steel with a volume of 250 ml and equipped with a facemask containing integrated inlet and outlet valves for inspiration and expiration, was compared with three plastic spacers. The plastic spacers were primed withRead more
Eur Respir J. 1995 May Bisgaard H. Abstract The low tidal volume and flow in preschool children may reduce the efficiency of aerosol delivery from a pressurized metered-dose inhaler (pMDI) through a traditional holding chamber. A prototype small-volume steel holding chamber with two one-way valves was devised to prolong aerosol availability in the chamber andRead more
J Cell Biol. 1994 Jul Nagy P, Bisgaard HC, Thorgeirsson SS. Abstract The oval cells are thought to be the progeny of a liver stem cell compartment and strong evidence now exists indicating that these cells can participate in liver regeneration by differentiating into different hepatic lineages. To better understand the regulation of this processRead more
J Cell Physiol. 1994 Jun Bisgaard HC, Nagy P, Ton PT, Hu Z, Thorgeirsson SS. Abstract Keratin 14 (K14) expression has recently been demonstrated in cell lines of non-parenchymal hepatic origin (Bisgaard et al., 1993, Mol. Carcinog., 7:60-66; Bisgaard et al., 1991, J. Cell. Physiol., 147:333-343). These cell lines are thought to represent a progenyRead more
J Cell Physiol. 1994 Jun Bisgaard HC1, Ton PT, Nagy P, Thorgeirsson SS. Abstract Several lines of evidence have indicated that rat liver epithelial (RLE) cell lines may be related to a dormant stem cell compartment in the liver in vivo. We have demonstrated that keratin 14 (K14) is expressed together with vimentin in undifferentiatedRead more
Eur Respir J. 1994 Apr Bisgaard H1, Pedersen S, Nikander K. Abstract The question addressed in this study was the ability of young children to use a dry-powder inhaler, Turbuhaler. One hundred and sixty five children suspected of asthma, equally distributed in one year age-groups from 6 months to 8 yrs, inhaled from a PulmicortRead more
J Aerosol Med. 1994 Bisgaard H. Abstract There is a mandatory need for effortless drug administration to young children since the prevalence among them of recurrent wheezing is a 15-20%. It is becoming increasingly evident that many of these children respond dramatically well to beta2-agonists and topical steroids; accordingly this sub-group of children should beRead more
