Allergy. 1988 Apr Bisgaard H, Robinson C, Rømeling F, Mygind N, Church M, Holgate ST. Abstract We have examined the measurements of LTC4 and histamine in nasal lavage fluids and blown secretions as a possible model of the early mediator events during nasal allergy. A nasal challenge with grass pollen extract was undertaken on twoRead more
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Allergy. 1988 Feb Lerche A, Bisgaard H, Christensen JD, Venge P, Dahl R, Søndergaard J. Abstract A skin window technique was used to study the morphology of leucocytes in upper dermis and exudate during nickel challenge in patients with contact allergy to nickel. Contact allergic patients and healthy volunteers tested with a skin widow withoutRead more
Acta Paediatr Scand. 1987 Sep Bisgaard H, Dalgaard P, Nyboe J. Abstract Risk factors for the development of wheezing during infancy were studied in 5,953 children. The data for the study were collected from a large prospective investigation of children born in 1959-61, who had attended a one-year follow-up examination. Wheezing was diagnosed when theRead more
Allergy. 1987 Jul Bisgaard H, Poulsen L, Søndergaard I. Abstract The process of nebulization and deposition of LTD4 was studied in detail. The concentration of LTD4 in a saline solution decreased by approximately 90% after 2 min of nebulization in a DeVilbiss 35B ultrasonic nebulizer. This decrease was prevented by diluting LTD4 in a phosphateRead more
Clin Sci (Lond). 1987 May Bisgaard H, Groth S. Abstract The aim of the study was to investigate whether inhaled leukotriene (LT) D4 could mimic the characteristics of asthmatic patients after allergen-induced attack, i.e. a prolonged subclinical bronchial obstruction, an increased reactivity of the airways and a late reaction. The effects of LTD4 were comparedRead more
Eur J Respir Dis. 1987 Mar Stafanger G, Bisgaard H, Pedersen M, Mørkassel E, Koch C. Abstract N-acetylcysteine (NAC) is widely used as a mucolytic agent, but the clinical and pharmacological effects of NAC are still unclear. It has recently been claimed in animal studies that NAC will stimulate ciliary beating frequency at low concentrations,Read more
Clin Allergy. 1987 Mar Bisgaard H, Pedersen M. Abstract We have studied the effects of the slow reacting substance of anaphylaxis (SRS-A) constituents leukotrienes (LT) C4 and D4 on the ciliary activity of human respiratory cells. The ciliary beat frequency on human nasal cells harvested by cell scraping from the inferior turbinate was measured inRead more
J Invest Dermatol. 1987 Feb Bisgaard H. Abstract Leukotriene D4 (LTD4) increased the blood flow rate in human skin, equipotent to histamine in the dose range of 3.1-200 pmol. The vasodilatation lasted for up to 60 min, and no late reactions occurred. Indomethacin did not affect the LTD4-induced blood flow rate. H1 and H2 antagonistsRead more
Clin Allergy. 1986 Jul Bisgaard H, Olsson P, Bende M. Abstract The possible role of leukotriene D4 (LTD4) in nasal allergy was investigated in healthy volunteers. Nasal blood flow, nasal airway resistance, nasal discharge and nasal itching and sneezing were examined. LTD4 was found to induce a dose-response related increase in nasal mucosal blood flowRead more
Allergy. 1986 Jul Bisgaard H, Helqvist S, Boudet L, Venge P, Dahl R, Søndergaard J. Abstract An improved skin window chamber technique has been developed and used for a quantitative study of the chemotactic effect of leukotriene B4 (LTB4). LTB4 (0.5 microM) was exposed to a skin window on the forearm of eight healthy volunteers,Read more
