J Invest Dermatol. 1986 Mar Bisgaard H, Kristensen JK, Sondergaard J. Abstract By combining laser-Doppler velocimetry with reactive hyperemia, induced by arterial occlusion of 4-min duration we have established a simple and atraumatic new ranking technique for assessing steroid potency. The experiments were performed in 19 healthy volunteers. Budesonide (Preferid) and placebo (vehicle) were appliedRead more
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Acta Derm Venereol. 1986 Kristensen JK, Karlsmark T, Bisgaard H, Søndergaard J. Abstract Three new parameters have been introduced to provide data for quantitative evaluation of peripheral cutaneous blood flow in patients with leg ulcers. Reactive hyperemia was induced by occlusion of the blood flow for four minutes at the thigh-level. Blood flow was subsequentlyRead more
Photodermatol. 1985 Dec Søndergaard J, Bisgaard H, Thorsen S. Abstract Several studies have implicated the eicosanoids as mediator substances in different types of UV inflammation. In human UV erythema, various arachidonic acid metabolites–mainly cyclooxygenase products–have been detected, particularly in skin exudates. The concentration and the sequence of release of the various eicosanoids vary in relationRead more
Prostaglandins. 1985 Nov Bisgaard H, Kristensen JK. Abstract During inflammation, pain receptors are sensitized by inflammatory mediators causing hyperalgesia. Leukotriene B4 (LTB4) is a potent chemoattractant for polymorphonuclear leukocytes in humans in vivo. In the present study we have demonstrated a reduction of the pain threshold in humans after intracutaneous deposition of LTB4. The painRead more
Allergy. 1985 Aug Bisgaard H, Ford-Hutchinson AW, Charleson S, Taudorf E. Abstract The production of leukotrienes has been monitored in tear fluids from subjects following a conjunctival provocation test, and skin blister fluids following initiation of a Prausnitz-Kustner reaction. In tear fluids elevated levels of leukotriene C4 (LTC4)-immunoreactive material were measured following allergen challenge asRead more
J Invest Dermatol. 1985 May Bisgaard H, Lerche A, Kristensen JK. Abstract The aim of the present study was to investigate the edema induced by leukotriene D4 (LTD4). Edema is the gross effect of increased blood flow and capillary permeability. Our objective was to elucidate the effect of LTD4 on edema generation without the influenceRead more
Br Med J (Clin Res Ed). 1985 May 18 Bisgaard H, Groth S, Madsen F. Abstract Reactivity of the small and large airways to inhaled leucotriene D4, one of the leucotrienes that constitute slow reacting substance of anaphylaxis, was studied in eight patients with exogenous asthma and nine healthy subjects with no history of atopy.Read more
Prostaglandins. 1985 Feb Bisgaard H, Kristensen JK. Abstract Prostaglandin E-1 and E-2 acts as vasodilators partly through inhibition of sympathetic nerves and partly through a direct action on smooth muscle. To elucidate the mechanisms of LTD-4 induced vasodilation, the vascular smooth muscle dependent auto-regulation of blood flow and the sympathetic reflex mechanism of the “vasoconstrictorRead more
J Invest Dermatol. 1984 Sep Bisgaard H, Kristensen JK. Abstract The cutaneous microcirculation is a desirable model for pharmacologic and physiologic studies of inflammatory mediators. For exact measurements of the induced blood flow changes, two objective methods are introduced. The laser-Doppler flowmeter and the 133Xe washout technique have formerly been used for measurement of theRead more
Allergy. 1984 Aug Svenson M, Bisgaard H, Bendtzen K. Abstract The effect of the leukotrienes LTB4, LTC4 and LTD4 on the production of the lymphokine leukocyte migration inhibitory factor (LIF) from human peripheral blood mononuclear cells was tested. LTC4 and LTD4 failed to influence LIF production by cells stimulated by antigen or the polyclonal TRead more
