Blog

Allergy. 1984 Aug Bisgaard H. Abstract Leukotrienes and prostaglandins possess properties which are central in the asthmatic reaction. They are bronchoconstrictors, they inhibit the mucociliary clearance, increase blood flow and permeability and thereby induce edema formation, and they attract and activate leukocytes. They are formed partly by allergic reactions and partly by a large numberRead more

Allergy. 1984 Jul Bisgaard H, Andersen JB, Bach-Mortensen N, Bertelsen A, Friis B, Koch C, Prahl P, Wichmann R, Osterballe O. Abstract Forty children with childhood asthma were conducted through a double-blind cross-over study to compare the effect of 400 micrograms beclomethasone dipropionate administered as aerosol and powder (Rotacaps). Children with severe asthma derived moreRead more

Prostaglandins. 1984 Apr Bisgaard H, Olsson P, Bende M. Abstract The effect of leukotriene D4 on the nasal mucosal blood flow in humans was measured using a laser doppler flow meter. The leukotriene solution was applied topically to the nasal mucosa in 9 healthy subjects, and changes in blood flow were measured non-traumatically by theRead more

Allergy. 1984 Apr Lerche A, Bisgaard H, Christensen JD, Søndergaard J. Abstract Ten nickel-allergic patients and six healthy control subjects participated in a study of the morphology, kinetics and evolution of the cAMP and cGMP concentrations of migrated leukocytes, using an improved skin chamber technique. Also studied was the effect of nickel exposure in theRead more

Prostaglandins. 1984 Mar Bisgaard H, Ford-Hutchinson AW, Charleson S, Taudorf E. Abstract Tear fluid was obtained from allergic subjects from control eyes and eyes challenged with specific allergen and levels of leukotriene C4 (LTC4)-immunoreactivity determined by radioimmunoassay. Formal identification of the leukotrienes released was not possible but the levels of LTC4-immunoreactive material in allergen-challenged tearRead more

Biomed Biochim Acta. 1984 Bisgaard H, Groth S, Taudorf E, Madsen F. Abstract The bronchoconstrictor effect of LTD4 was tested in a double blind design in 9 healthy volunteers who inhaled 10 and 40 nmol synthetic LTD4, 10 and 100 mumol histamine, and placebo on 5 different days. As the nebulized testsolutions were administered viaRead more

Allergy. 1983 Aug Bisgaard H, Groth S, Dirksen H. Abstract The effect of leukotriene D4 (LTD4) on lung function was investigated in a controlled study on four normal subjects. A pronounced decrease in airflow was found after inhalation of less than 0.5 nmol, and was most pronounced in the variables generally accepted as indicators ofRead more

Br J Dermatol. 1983 Jul Bisgaard H, Kristensen J, Sondergaard J. Abstract By quantifying the flare response, leukotrienes LTC4 and LTD4 were shown to increase the microcirculatory flow in a sigmoidal dose-response relation over the dose-range of 6.25-800 pmol. LTD4 was found to be more potent than LTC4 after 5 min, but not after 15Read more

Prostaglandins. 1982 Jun Bisgaard H, Kristensen J, Søndergaard J. Abstract Using a laser-Doppler-flowmeter the microvascular response to LTC4 and LTD4 was measured. Intradermal injection of 1 microgram LTC4 and LTD4 caused an increase in the microvascular cutaneous bloodflow. The increase in flow was equal to that caused by histamine in equimolar amounts. Blocking the triple-responseRead more

Acta Derm Venereol. 1981 Lerche A, Bisgaard H, Christensen JD, Søndergaard J. Abstract An improved skin chamber technique has been devised and used for quantitative evaluation of the leukocyte mobilization rate (LMR). The method was applied in 10 nickel-hypersensitive patients exposed to nickel sulphate. Each patient served as his own control and for additional controlRead more