Allergy. 2016 Mar Divergent response profile in activated cord blood T cells from first-born child implies birth-order-associated in utero immune programming. Kragh M, Larsen JM, Thysen AH, Rasmussen MA, Wolsk HM, Bisgaard H, Brix S. Author information Abstract BACKGROUND: First-born children are at higher risk of developing a range of immune-mediated diseases. The underlying mechanismRead more
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Eur J Epidemiol. 2016 Mar;31(3):325-9. Childhood asthma is consistently reported to have increased in recent decades in most westernized countries, but it is unknown if this increase is similar across severities. We aimed to study the time-trend of acute hospital admission and readmission for asthma of school-aged children in the recent 35 years in Denmark. WeRead more
Lancet Respir Med. 2016 Mar;4(3):e8-9. PMID: 26973163Read more
Eur J Epidemiol. 2016 Mar Sevelsted A, Pipper CB, Bisgaard H. Abstract Childhood asthma is consistently reported to have increased in recent decades in most westernized countries, but it is unknown if this increase is similar across severities. We aimed to study the time-trend of acute hospital admission and readmission for asthma of school-aged childrenRead more
Pediatr Infect Dis J. 2016 May;35(5):561-6. Vissing NH, Larsen JM, Rasmussen MA, Chawes BL, Thysen AH, Bønnelykke K, Brix S, Bisgaard H BACKGROUND Neonatal colonization of the airways with respiratory pathogens is associated with increased risk of lower respiratory infections (LRI) in early childhood. Therefore, we hypothesized that children developing LRI have an aberrant immuneRead more
Allergy. 2016 May;71(5):684-91. Schoos AM, Chawes BL, Jelding-Dannemand E, Elfman LB, Bisgaard H RATIONALE Allergen exposure is associated with the development of allergic sensitization in childhood as reflected by global variations in sensitization patterns. However, there is little evidence to support a direct association. OBJECTIVES To investigate the association between perinatal aeroallergen exposure and sensitizationRead more
IMPORTANCE Observational studies have suggested that increased dietary vitamin D intake during pregnancy may protect against wheezing in the offspring, but the preventive effect of vitamin D supplementation to pregnant women is unknown. OBJECTIVE To determine whether supplementation of vitamin D3 during the third trimester of pregnancy reduces the risk of persistent wheeze in theRead more
A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discoveryRead more
J Pediatr. 2016 Apr;171:38-42.e4. Sevelsted A, Stokholm J, Bisgaard H OBJECTIVE To assess our prospective mother-child cohort and the national registry data to analyze the risk of asthma by delivery mode and whether cesarean delivery before or after membrane rupture affects this risk differently. STUDY DESIGN The Copenhagen Prospective Studies on Asthma in Childhood2000 isRead more
Lancet Respir Med. 2016 Jan;4(1):19-26. BACKGROUND Bacteria and viruses are equally associated with the risk of acute episodes of asthma-like symptoms in young children, suggesting antibiotics as a potential treatment for such episodes. We aimed to assess the effect of azithromycin on the duration of respiratory episodes in young children with recurrent asthma-like symptoms, hypothesisingRead more
